Name: 5-HTP
Brand: Ethical Nutrition
SKU: 3260
Price: 20.0 GBP
Availability: InStock

60 capsules | 30 day supply

✔ MOOD ✔ SLEEP

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Support your sleep cycle, mood, appetite and more with our naturally derived 5-HTP (5-hydroxytryptophan). Extracted from responsibly sourced Griffonia simplicifolia seeds, our 5-HTP provides natural assistance for serotonin and melatonin production to optimise mood, sleep, and mental wellbeing. Each dose delivers 200mg of 5-HTP with no artificial additives or fillers, just pure ingredients for maximum effectiveness.

2 capsules provide:

Ingredient	Amount
5-HTP (Griffonia simplicifolia extract)	200mg

Ingredients: Rice Flour & Extract (Oryza Sativa), Griffonia Seed Extract (Griffonia simplicifolia), Capsule Shell (Vegetable Cellulose).

Take 2 capsules daily, preferably with food.

For best results, take in the evening to support natural serotonin and melatonin production.

At Ethical Nutrition, quality and safety come first - every ingredient, every batch.

Independent Lab Testing
Before any ingredient is used in production, it’s tested by accredited third-party laboratories for heavy metals and microbiological contaminants. Only materials that meet our strict standards move forward to become part of your supplement.

Full Batch Transparency
We believe in clear, honest communication. That’s why we share a summary of the latest test results for every product batch. If you’d like to see a previous batch, just drop us a message at hello@ethical-nutrition.com and we’ll be happy to help.

Made to the Highest Standards
Our products are manufactured in a BRCGS Grade AA certified facility and produced under strict Good Manufacturing Practice (GMP) guidelines. These certifications ensure robust controls around cleanliness, traceability, ingredient quality, and packaging.

Exceptional Allergen Control
We follow rigorous allergen management procedures from goods-in through to dispatch. Dedicated cleaning routines, thorough risk assessments, and segregated storage help minimise cross-contamination risks—making our supplements a safer choice for sensitive individuals.

100% Clean Formulas
You won’t find any unnecessary fillers, binders or additives in our supplements. They’re free from GMOs, palm oil, flavourings and the top 14 allergen-containing ingredients (including gluten, dairy, soy, and nuts). All of our products are registered with the Vegan Society.

We do the hard work behind the scenes so you can trust what’s in the capsule.

Made in the UK to GMP standards.

Plastic-free, recyclable packaging.

Family-owned business.

100% clean formula.

Suitable for vegetarians and vegans. All Ethical Nutrition products are free from animal-based ingredients and by-products. Registered with the vegan society.

Free-from: GMOs, Magnesium Stearate, Gelatin, Palm Oil/Palm Oil Derivatives, Maltodextrin, Bulking Agents, Titanium Dioxide, Sugar.

No Allergen-Containing Ingredients: This product is formulated without any ingredients from the top 14 allergens, including wheat, milk, nuts, soy, and shellfish.

Additive-free: We don't use any nasty additives and where required we use gluten-free rice extract to help us to blend together ingredients and ensure they are accurately dosed.

5-HTP is 5-hydroxytryptophan, an intermediate metabolite of the amino acid l-tryptophan. It is produced during the conversion of tryptophan to serotonin [1].

Tryptophan is found in protein-rich foods like soy beans, cottage cheese, fish, red meat, lentils, and seeds. However, food sources may not be enough to manage a specific health issue and tryptophan itself is not available as a supplement in the UK. Instead, we use 5-HTP which is one step further along the pathway to serotonin production.

Serotonin influences a range of behaviours including mood, sleep, digestion, and appetite. It also converts to melatonin, the hormone that regulates circadian rhythms and the onset of sleep [2]. 5-HTP is used to support the production of both serotonin and melatonin.

Here at Ethical Nutrition we use 5-HTP extracted from the seeds of an African plant called Griffonia simplicifolia.

5-HTP has benefits for:

Depression. Due to its ability to cross the blood-brain-barrier and support serotonin production, 5-HTP has a long history of use in managing depression [3].
Managing anxiety. 5-HTP has been shown to be effective on its own or in conjunction with other medications to ease anxiety [4].
Enhancing sleep via increased melatonin production. This is known to be especially beneficial for older people as the ageing process can reduce serotonin production, serotonin receptor sensitivity, and melatonin production. One study using 100mg 5-HTP per day demonstrated significant improvements in sleep quality in older adults, along with improvements in the gut microbiota [5].
Regulating appetite. Serotonin is involved in regulating appetite and food intake. Some research shows that 5-HTP can influence body composition and support weight loss in overweight individuals [6].
Fibromyalgia. Although there is no known cause for fibromyalgia, it is associated with low serotonin levels. Some research suggests that 5-HTP can improve fibromyalgia symptoms like pain, anxiety, and poor sleep [7].

5-HTP may benefit people who are managing:

Low mood
Anxiety
Depression
Insomnia
Poor quality sleep
Weight balance
Fibromyalgia

Melatonin is a hormone produced primarily in the pineal gland in response to the onset of dusk. As evening progresses, your brain releases more melatonin to help you fall asleep.

5-HTP is converted to serotonin in the body which is then further converted into melatonin. Supplementing with 5-HTP may support melatonin levels.

It depends on why you are taking it. If you want to enhance sleep, take 5-HTP with your evening meal or a small evening snack. Otherwise, take it with food at a time of day that suits you.

Yes, 5-HTP can potentially interact with several medications including antidepressants and sedatives. We recommend you speak to your healthcare provider before using 5-HTP alongside any prescription medications or other supplements, or when pregnant or breastfeeding.

When taken as directed 5-HTP is well tolerated with few potential side effects.

Some people may experience temporary mild nausea, upset stomach, loose stools, headaches, or drowsiness.

Richard, D.M., Dawes, M.A., Mathias, C.W., Acheson, A., Hill-Kapturczak, N., Dougherty, D.M. 2009. L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications. International Journal of Tryptophan Research Mar 23;2:45-60. doi: 10.4137/ijtr.s2129. PMID: 20651948; PMCID: PMC2908021.
Szczepanik M. Melatonin and its influence on immune system. 2007. Journal of Physiology and Pharmacology. Dec;58 Suppl 6:115-24. PMID: 18212405.
Maffei, M. E. 2020. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. International Journal of Molecular Sciences, 22(1), 181. https://doi.org/10.3390/ijms22010181
Kahn, R.S., Westenberg, H.G. 1985. L-5-hydroxytryptophan in the treatment of anxiety disorders. Journal of Affective Disorders. Mar-Apr;8(2):197-200. doi: 10.1016/0165-0327(85)90046-1
Sutanto, C. N., Xia, X., Heng, C. W., Tan, Y. S., Lee, D. P. S., Fam, J., & Kim, J. E. 2024. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial. Clinical Nutrition, 43(3), 593-602. https://doi.org/10.1016/j.clnu.2024.01.010
Ioannou, S., & Williams, A. L. 2016. Preliminary fMRI findings concerning the influence of 5‐HTP on food selection. Brain and Behavior, 7(1), e00594. https://doi.org/10.1002/brb3.594
Caruso, I., Puttini, P. S., Cazzola, M., & Azzolini, V. 1990. Double-Blind Study of 5-Hydroxytryptophan versus Placebo in the Treatment of Primary Fibromyalgia Syndrome. Journal of International Medical Research. https://doi.org/10.1177/030006059001800304